Accelerated biological aging in COVID-19 patients | Nature Communications

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual’s chronological age (r > 0.8, p < 0.0001). We also find the increasing acceleration of epigenetic aging and telomere attrition in the sequential blood samples from healthy individuals and infected patients developing non-severe and severe COVID-19. In addition, the longitudinal DNA methylation profiling analysis find that the accumulation of epigenetic aging from COVID-19 syndrome could be partly reversed at late clinic phases in some patients. In conclusion, accelerated epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. In addition, the accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome among survivors. Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations between epigenetic aging and the risk of SARS-CoV-2 infection and severe disease.
— Read on www.nature.com/articles/s41467-022-29801-8

A cualquier hora

Santiago Galicia Rojon Serrallonga

SANTIAGO GALICIA ROJON SERRALLONGA

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Y una mañana, una tarde, una noche o una madrugada, a cierta hora, en cualquier estación -en primavera, cuando la vida pinta colores en el lienzo de la naturaleza; en verano, mientras llueve y los relámpagos alumbran y rasgan las nubes plomadas; en otoño, al desprender el viento las hojas de los árboles y dispersarlas aquí y allá; en invierno, al cubrir la nieve el paisaje-, uno llega puntual y de frente a su destino, carente de equipaje y sin maquillajes, simplemente con la historia de su travesía existencial.

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A “spicy” boost for Jamaican agriculture

Petchary's Blog

There was a sixties song called “Sugar and spice and all things nice” – in praise of a sweet girlfriend, by a Liverpool band called The Searchers. In Jamaica, we have a dancehall artiste named Spice; and a chain of spicy pastry shops, too.

As far as our agriculture is concerned, “King Sugar,” as it was once called, is on the wane – while spice is (hopefully) on the rise again. When I was in Grenada, I was struck by how the marketing of the island was centred around just one spice – nutmeg (in fact, that’s two spices, as the nutmeg seed’s covering, mace, has a subtle flavour all its own). Then, this very small island has another ace up its sleeve: its delicious organic chocolate.

These are valuable crops, with a lot of “value added” potential, too.

Spice products on display. (My photo)

So, it’s time Jamaica started…

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Busca

Pensamentos.me/VEM comigo!

A emergência é sempre pela busca; a busca genuína da felicidade, da razão, do que potencializar a vida, o amor. A busca! Sempre estamos aos berros, brigando, pedindo, suplicando. Afinal, que falta é essa que eu e você carregamos? Por que será que por dentro e por fora, sempre estamos despidos de alguma coisa. Às vezes, estamos despidos de qualquer racionalidade, aliviados de qualquer desfecho trágico, diria. Eu não conseguiria dizer em palavras aonde o homem transgride tanto para viver sempre se queixando. É um blá, blá, blá paliativo, é um recapitulando alguma coisa (…) Isso é o que chamamos de vida, quer dizer, todos os nossos olhares se voltam para as mesmas coisas? De mau humor, se comete burrices medonhas. Já se usando a inteligência, também falta alguma coisa.
Aliás, e você? Já viajou na minha interpretação, certamente. De serenidade eu ando cheia. A mulher precisa encontrar um lugar…

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