Category Archives: TB

Online health hoaxes: The place where bleach “cures” autism and vaccines spread epidemics | In English | EL PAÍS

There is a place where cancer can be cured in just 42 hours and where all the doctors in the world are conspiring to deceive the population. It is a place where you can “cure” autism with bleach, and where vaccines, far from preventing epidemics, actually spread them. This place is called social media, where a losing battle is being waged on a daily basis against dangerous health hoaxes and misinformation. In Spain, the internet is the second most important source of information on pseudotherapies, and two-thirds of citizens go online to read up on health issues.

Source: Online health hoaxes: The place where bleach “cures” autism and vaccines spread epidemics | In English | EL PAÍS

How drug resistant TB evolved and spread globally – European colonialism!

The most common form of Mycobacterium tuberculosis (TB) originated in Europe and spread to Asia, Africa and the Americas with European explorers and colonialists, reveals a new study led by UCL and the Norwegian Institute of Public Health.

Source: How drug resistant TB evolved and spread globally

New Klebsiella strains ‘worst-case scenario,’ experts say | CIDRAP “Pandemic watch…”

While the overall prevalence of hypervirulent, drug-resistant K pneumoniae in China appears to be low, Chen said, what he and his colleagues are worried about is that it will likely increase in Chinese hospitals, presenting clinicians with more severe infections that don’t respond to the current arsenal of antibiotics.But with few new antibiotics in the pipeline, physicians will be forced to keep using what they have, which will only hasten the further emergence of multidrug-resistant pathogens, said David van Duin, MD, PhD, an antimicrobial resistance researcher at the University of North Carolina School of Medicine. “Emergence of combined increased virulence and resistance will force doctors to treat patients even more broadly upfront with last-line antibiotics, thus inducing additional resistance,” he said.And if the rapid global spread of the resistance gene MCR-1 is any example, these types of infections won’t be limited to China. The plasmid-mediated gene, which confers resistance to the last-resort antibiotic colistin, was identified in Escherichia coli bacteria in China in 2015, and since then has been detected in more than 30 countries. Other antibiotic resistance genes have demonstrated similar ability to spread rapidly via horizontal gene transfer. The genes and plasmids, and the bacteria that carry them, know no boundaries.”Multidrug-resistant organisms in one part of the world are a threat to patients everywhere,” van Duin said.

Source: New Klebsiella strains ‘worst-case scenario,’ experts say | CIDRAP

Report warns of rise in drug-resistant tuberculosis | CIDRAP

Growing drug resistance

According to the report, approximately 20% of TB cases globally are estimated to be resistant to at least one of the first- or second-line anti-TB drugs, and 5% are resistant to both isoniazid and rifampicin, the most powerful and commonly used antibiotics in first-line treatment. Of the estimated 480,000 cases of multidrug-resistant (MDR) TB, approximately 10% are either extensively drug-resistant (XDR)—with additional resistance to second-line drugs—or totally drug resistant.While TB is curable when patients adhere to the treatment regimen, MDR- and XDR-TB are more problematic. Treatment options are limited, expensive, and often toxic, and drug therapy can last up to 2 years. The report estimates mortality rates of around 40% for MDR-TB and 60% for XDR-TB. And while China, India, Russia, and South Africa have the highest burden of MDR- and XDR-TB, widespread international travel and migration means drug-resistant TB has no borders.Although shorter treatment regimens and new drugs are providing hope for some MDR- and XDR-TB patients, the authors of the report say the fight against drug-resistant TB has to be fought on several fronts.  “Addressing drug-resistant tuberculosis requires an urgent and concerted effort to manage the disease and prevent onward transmission with sustained research to develop and assess new tools,” the authors write.

Source: Report warns of rise in drug-resistant tuberculosis | CIDRAP

Republican lawmaker says cancer patients can go to the ER for health care – Shareblue

Like many Republicans, DeSantis either does not know or does not care that 73 percent of Medicaid recipients do, in fact, work, or that the whole point of medical insurance is that even “able-bodied” people like Tiffany Koehler are only “able-bodied” until they are not.Neither the current GOP plan nor the potentially harsher options waiting in the wings recognize the fundamental fact that under repeal, millions of Americans will lose insurance — a life or death prospect for thousands of people.

Source: Republican lawmaker says cancer patients can go to the ER for health care – Shareblue

SuperSpreader Spin – Making Money and Status from Pandemic News

Pandemic SuperSpreader Spin – this is how spin works to advance status of scientists (income and power) and advance commercial interests of for profit and not-for-profit publications.

  1. Create a new term for a known phenomena and it seems new and thus newsworthy.
  2. Since people have been studying the spread of disease, it has been know that a small number of people can and are responsible for spreading disease quickly if they come in close contact with a large number of people in a short space of time. “Typhoid Mary” was a carrier who worked in restaurants in New York City and could thus come into contact with a large number of people visiting a restaurant where she was employed.
  3. A modern version could be because an ill person has greater mobility than in earlier times. A person who is contagious for influenza or TB could potentially infect hundreds of people in a flight from Manila to Hawaii, Los Angeles and New York City and subway trip home with two transfers and a stop at a local fast food restaurant before going to a welcome home party.
  4. Employ might, could perhaps and maybe to add to spin.

When a new term is spun here can be the overnight result:

Ebola Study Shows How ‘Superspreaders’ Can Prolong An Outbreak

Huffington Post – ‎15 hours ago‎

A new analysis points to the role that “superspreaders” have in prolonging infectious disease outbreaks. Disease “superspreaders” may have played a major role in the spread of the Ebola virus during the 2014 outbreak in West Africa, according to a new …

Ebola “Super Spreaders” Responsible for Most Cases in Last Outbreak

Morocco World News – ‎Feb 15, 2017‎

Rabat – New research has found the majority of cases in the Ebola outbreak of 2014-2015 were caused by the phenomenon of “super spreaders,” according to BBC News. Super spreaders are small pockets of infected individuals who pass a virus on to a …

Superspreaders Caused Much of the 2014 Ebola Epidemic

Smithsonian – ‎Feb 15, 2017‎

Ebola. World Health Organization workers gear up to go into an old Ebola isolation ward in Lagos, Nigeria. (CDC – Flickr/Creative Commons). By Erin Blakemore. smithsonian.com. February 15, 2017 10:47AM. 0 0 0 0 0 0 0. 0 0 0 0 0 0. In 2014 and 2015, …

Super Spreaders Caused Most Cases Of Ebola

Counsel & Heal – ‎Feb 15, 2017‎

MONROVIA, LIBERIA – AUGUST 18: Public health advocates stage an Ebola awareness and prevention event on August 18, 2014 in Monrovia, Liberia. The Liberian government and international groups are trying to convince residents of the danger and are …

Ebola Superspreaders: 3 Percent Infected 61 Percent of Victims

Newsmax – ‎Feb 15, 2017‎

Ebola “superspreaders,” a small percentage of those infected by the disease in West Africa did the most damage by infecting others, according to a new study looking back at the 2014-15 epidemic. The study, published this week in the journal Proceedings

West Africa: Ebola Epidemic Fuelled By ‘Super-Spreaders’ – Study

AllAfrica.com – ‎Feb 15, 2017‎

Most of the people who were infected with Ebola in the 2014 West Africa epidemic contracted the viral disease through “super-spreaders”, researchers say. According to a study published on Monday in the Proceedings of the National Academy of Sciences, …

Small percentage of patients found responsible for spreading lethal Ebola epidemic

NORCAL – ‎Feb 15, 2017‎

A small percentage of so-called “superspreaders” was likely responsible for spreading the lethal Ebola epidemic that left thousands of people dead in West Africa, according to a new study. A team of experts from New Jersey’s Princeton University and

Ebola ‘super-spreaders’ cause most cases

Walta Information Center (blog) – ‎Feb 14, 2017‎

The majority of cases in the world’s largest outbreak of Ebola were caused by a tiny handful of patients, research suggests. The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused

Ebola ‘Superspreaders’: Faster Contamination Basically Through Contacts of Bodily Fluids

Latin Post – ‎Feb 14, 2017‎

In 2014, the greater part of the population infected in West Africa got wiped out through contact with the disease called Ebola. Though Typhoid Mary was the most superspreader, which has infected 51 individuals, and three of whom passed in the vicinity

Small Percentage of Ebola Patients Found Responsible for Most Cases in Epidemic

Voice of America – ‎Feb 14, 2017‎

FILE – Health workers carry the body of a suspected Ebola victim for burial at a cemetery in Freetown, Sierra Leone, Dec. 21, 2014. Share. Share on Facebook · Share on Twitter · Share on Google+ · Email to a Friend. Print. See comments. WASHINGTON —.

‘Superspreaders’ Are Responsible For The 2014 Ebola Outbreak, Study Says

Medical Daily – ‎Feb 14, 2017‎

A new study finds that a small number of people, referred to as ‘superspreaders,’ may have been responsible for nearly two-thirds of Ebola cases during the 2014-2015 epidemic in West Africa. Although superspreaders have been previously thought to play

Study: Disease ‘superspreaders’ accounted for nearly two-thirds of Ebola cases

Lexington Herald Leader – ‎Feb 14, 2017‎

They are called the superspreaders, the minority of people who are responsible for infecting many others during epidemics of infectious diseases. Perhaps the most famous superspreader was Typhoid Mary, presumed to have infected 51 people, three of …

Researchers Document Dynamics of Superspreading Events in the 2014-2015 West Africa Ebola Epidemic

Infection Control Today – ‎Feb 14, 2017‎

For many infections, some infected individuals transmit to disproportionately more susceptibles than others, a phenomenon referred to as “superspreading.” Understanding superspreading can facilitate devising individually targeted control measures

Ebola epidemic fuelled by ‘super-spreaders’: study

MWC News (satire) (registration) (blog) – ‎Feb 14, 2017‎

Scientists say small percentage of people were the cause of most cases of Ebola virus that ravaged West Africa in 2014. Most of the people who were infected with Ebola in the 2014 West Africa epidemic contracted the viral disease through “super

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

ReliefWeb – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Small Percentage Of People Infected With Ebola Considered ‘Superspreaders,’ Responsible For 61% Of Cases In West …

Kaiser Family Foundation – ‎Feb 14, 2017‎

“Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of ‘superspreaders’ with the disease, researchers said Monday…” (2/13). International Business Times: Sierra Leone

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Thomson Reuters Foundation – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

“Superspreaders” Caused Almost Two-Thirds Of Ebola Cases In Recent Outbreak

IFLScience – ‎Feb 14, 2017‎

Infecting tens of thousands of people, and claiming the lives of almost half of those, the outbreak of Ebola a few years back was the worst ever experienced. But it now seems that the vast majority of those who were infected with the disease contracted

Disease ‘superspreaders’ accounted for nearly two-thirds of Ebola cases, study finds

Pharmacy Today, American Pharmacists Association, pharmacist.com – ‎Feb 14, 2017‎

Scientists report that superspreaders accounted for a majority of the Ebola virus cases in the 2014–15 epidemic in West Africa. Scientists report that superspreaders accounted for a majority of the Ebola virus cases in the 2014–15 epidemic in

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Cyprus Mail – ‎Feb 14, 2017‎

Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases of the disease, which ravaged the West African

Small percentage of people spread most Ebola cases: Study

Geo News, Pakistan – ‎Feb 14, 2017‎

Most of the people who were infected with Ebola in the 2014 West Africa epidemic contracted the viral disease through “super-spreaders”, researchers say. According to a study published on Monday in the Proceedings of the National Academy of Sciences, …

Disease ‘superspreaders’ fueled West Africa Ebola epidemic: researchers

Reuters – ‎Feb 14, 2017‎

DAKAR (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases of the

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Reuters – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Thomson Reuters Foundation – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Thomson Reuters Foundation – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

RTE.ie – ‎Feb 14, 2017‎

Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers have said. Six in 10 cases of the disease, which ravaged the West African

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Daily News & Analysis – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Daily Mail – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Disease ‘superspreaders’ fuelled West Africa Ebola epidemic – researchers

Thomson Reuters Foundation – ‎Feb 14, 2017‎

DAKAR, Feb 14 (Thomson Reuters Foundation) – Most people infected with Ebola in the world’s worst outbreak of the deadly virus contracted it from just a tiny fraction of patients known as “superspreaders”, researchers said on Tuesday. Six in 10 cases

Study reveals small percentage of people spread most cases

Pulse Nigeria – ‎Feb 14, 2017‎

The West African Ebola epidemic was the largest in history and killed more than 11,300 people. Published: 14.02.2017; Pulse News Agency International By AFP. Print; eMail · An MSF facility treating ebola in Kailahun in 2014 play. An MSF facility

Small percentage of people spread most Ebola cases: Study

Times of India – ‎Feb 14, 2017‎

MIAMI: Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National

Just 3 percent of Ebola Patients Were ‘Super-Spreaders’ Who Caused Majority of Cases: Study

Newsweek – ‎Feb 14, 2017‎

Almost two-thirds of cases in the West African Ebola outbreak were caused by just 3 percent of infected people, according to a study. The research, published in Proceedings of the National Academy of Sciences (PNAS), highlighted the role of so-called …

Ebola ‘super-spreaders’ cause most cases

The Kathmandu Post – ‎Feb 13, 2017‎

Feb 14, 2017- The majority of cases in the world’s largest outbreak of Ebola were caused by a tiny handful of patients, research suggests. The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61

Ebola epidemic fuelled by ‘super-spreaders’: study

Aljazeera.com – ‎Feb 13, 2017‎

Scientists say small percentage of people were the cause of most cases of Ebola virus that ravaged West Africa in 2014. 14 Feb 2017 06:40 GMT. Listen to this page using ReadSpeaker. 0; All Social. The West Africa outbreak began in Guinea in early 2014 …

Sierra Leone: ‘Superspreading’ accounted for more than 60% of Ebola cases

Yahoo News – ‎Feb 13, 2017‎

Just 3% of people with Ebola were involved in about 61% of transmissions of the disease in the 2014-15 epidemic in West Africa. The study also found that superspreaders had the most influence on the spread of Ebola in the tail-end of the epidemic.

Small percentage of people spread most Ebola cases: study

New Vision – ‎Feb 13, 2017‎

Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National Academy of …

Ebola ‘super-spreaders’ cause most cases

BBC News – ‎Feb 13, 2017‎

The majority of cases in the world’s largest outbreak of Ebola were caused by a tiny handful of patients, research suggests. The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused

Ebola ‘super-spreaders’ cause most cases

Mo4ch News (press release) (blog) – ‎Feb 13, 2017‎

The majority of cases in the world’s largest outbreak of Ebola were caused by a tiny handful of patients, research suggests. The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused

Ebola spread by small number of infected people

The Asian Age – ‎Feb 13, 2017‎

The West African Ebola epidemic was the largest in history and killed more than 11,300 people. If superspreading had been completely under control about two-thirds of Ebola cases could have been avoided (Photo: AFP). Miami: Most of the people infected …

Small percentage of infected people responsible for ebola epidemic: study

Deccan Chronicle – ‎Feb 13, 2017‎

Miami: Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National

Ebola ‘superspreaders’ accounted for nearly two-thirds of infections, study finds

South China Morning Post – ‎Feb 13, 2017‎

They are called the superspreaders, the minority of people who are responsible for infecting many others during epidemics of infectious diseases. Perhaps the most famous superspreader was Typhoid Mary, presumed to have infected 51 people, three of …

Ebola ‘super-spreaders’ cause most cases

BBC News – ‎Feb 13, 2017‎

The majority of cases in the world’s largest outbreak of Ebola were caused by a tiny handful of patients, research suggests. The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused

Superspreaders Drove Ebola Epidemic, Study Finds

41 NBC News – ‎Feb 13, 2017‎

Medical staff at the Hastings Ebola Treatment Center work to escort a man in the throes of Ebola-induced delirium back into the isolation ward from which he escaped in Hastings, Sierra Leone on Sunday, November 23, 2014. Pete Muller / Prime for

Small Percentage Of People Spread Most Ebola Cases: Study

Times Now – ‎Feb 13, 2017‎

Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National Academy of …

Superspreaders Drove Ebola Epidemic, Study Finds

NBCNews.com – ‎Feb 13, 2017‎

The story is well known among Ebola experts – the traditional healer who died from the virus in Sierra Leone and whose body infected 13 mourners at her funeral, who in turn infected more than 300 other people. It’s called a “superspreading” event, and

Disease ‘superspreaders’ accounted for nearly two-thirds of Ebola cases, study finds

Reading Eagle – ‎Feb 13, 2017‎

They are called the superspreaders, the minority of people who are responsible for infecting many others during epidemics of infectious diseases. Perhaps the most famous superspreader was Typhoid Mary, presumed to have infected 51 people, three of …

Small percentage of people spread most Ebola cases: study

Yahoo News – ‎Feb 13, 2017‎

Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National Academy of …

Disease ‘superspreaders’ fueled the Ebola epidemic: Two thirds of cases traceable to highly infection minority

Daily Mail – ‎Feb 13, 2017‎

Disease ‘superspreaders’ fueled the spread of the devastating Ebola epidemic in 2014, a new study claims. The West African Ebola epidemic was the largest in history and killed more than 11,300 people, with many of the cases involving people infected …

Small percentage of people spread most Ebola cases: study

Yahoo News – ‎Feb 13, 2017‎

Miami (AFP) – Most of the people infected with Ebola in the West Africa epidemic that began in 2014 got sick through contact with a small number of “superspreaders” with the disease, researchers said Monday. The study in the Proceedings of the National …

Disease ‘superspreaders’ accounted for nearly two-thirds of Ebola cases, study finds

Washington Post – ‎Feb 13, 2017‎

They are called superspreaders, the minority of people who are responsible for infecting many others during epidemics of infectious diseases. Perhaps the most famous superspreader was Typhoid Mary, presumed to have infected 51 people, three of whom …

Disease ‘superspreaders’ were driving cause of 2014 Ebola epidemic

EurekAlert (press release) – ‎Feb 13, 2017‎

CORVALLIS, Ore. – A new study about the overwhelming importance of “superspreaders” in some infectious disease epidemics has shown that in the catastrophic 2014-15 Ebola epidemic in West Africa, about 3 percent of the people infected were ultimately …

Sierra Leone: Ebola ‘superspreaders’ accounted for over 60% of cases

International Business Times UK – ‎Feb 13, 2017‎

Understanding people and contexts which increase the risk of superspreading could help contain future epidemics. Martha Henriques. By Martha Henriques. Updated February 14, 2017 09:58 GMT. Ebola Red Cross workers in the Ebola outbreak in Liberia in …

Disease ‘superspreaders’ were driving cause of 2014 Ebola epidemic

Medical Xpress – ‎Feb 13, 2017‎

The Ebola virus, isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells in a BSL-4 suite at Rocky Mountain Laboratories. Credit: NIAID. A new study about the overwhelming importance of …

This ‘Scorecard’ Makes it Easier to Fight Ebola Outbreaks

Newsweek – ‎Feb 13, 2017‎

A Doctors Without Borders health worker carries a child suspected of having Ebola in October 5, 2014 in Paynesville, Liberia. A new scoring system that calculates the severity of an Ebola case could help fight outbreaks and save lives. John Moore/Getty.

‘True Scale’ of India’s Tuberculosis Problem: 2.8 Million New Cases – The New York Times

Finally coming to terms with the enormity of its tuberculosis problem, India is preparing a radical overhaul and expansion of its national treatment program to fight an affliction that kills more adults worldwide than any other infectious disease.The severity of the matter was underscored on Thursday when the World Health Organization substantially increased its estimate of the number of new patients with TB in India, to 2.8 million in 2015, compared with 2.2 million in 2014 — more than in any other country in the world and more than a quarter of the world total.

Source: ‘True Scale’ of India’s Tuberculosis Problem: 2.8 Million New Cases – The New York Times

‘True Scale’ of India’s Tuberculosis Problem: 2.8 Million New Cases – The New York Times

Finally coming to terms with the enormity of its tuberculosis problem, India is preparing a radical overhaul and expansion of its national treatment program to fight an affliction that kills more adults worldwide than any other infectious disease.The severity of the matter was underscored on Thursday when the World Health Organization substantially increased its estimate of the number of new patients with TB in India, to 2.8 million in 2015, compared with 2.2 million in 2014 — more than in any other country in the world and more than a quarter of the world total.

Source: ‘True Scale’ of India’s Tuberculosis Problem: 2.8 Million New Cases – The New York Times

Curcumin may help fight drug-resistant tuberculosis | Vaccine News

Asians have long used turmeric to treat a variety of health conditions. Turmeric also has antioxidant, anti-inflammatory, and potentially anticancer properties. The health investigators discovered that provoking macrophages, which are human immune cells, can fight off experimentally infected cells within cultures. The infected cells have Mycobacterium TB, which causes TB bacteria to grow and spread through humans. Curcumin is able to stimulate these macrophages to fight the disease. This process was able to activate a cellular molecule, nuclear factor-kappa B. Curcumin can modulate the immune system against Mycobacterium TB, which suggests that it could be used as a new TB treatment that wouldn’t cause as much drug-resistance as traditional methods. “Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells,” Dr. Xiyuan Bai, lead author of the study that appears in Respirology, said. “The protective role of curcumin to fight drug-resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug-resistant tuberculosis.”

Source: Curcumin may help fight drug-resistant tuberculosis | Vaccine News

Johns Hopkins researchers identify TB’s natural resistance to antibiotics

Johns Hopkins University School of Medicine biophysicists recently found that the bacteria causing tuberculosis (TB) may be naturally resistant to antibiotics, called fluoroquinolones, which could help researchers strengthen TB drugs that have weakened over time. The biophysicists made this discovery using maps that showed 3-D details of the structure of the drugs while the medicines interacted with TB’s essential enzyme. “Front-line treatments for TB are eroding rapidly as more cases of multidrug-resistant TB arise worldwide,” Dr. James Berger, professor of biophysics and biophysical chemistry, said. “Our work helps show that we need not — and indeed should not — give up on fluoroquinolones, a longtime weapon in the fight against disease-causing bacteria in general. We’ve helped to identify several promising possibilities for developing new versions of these drugs that might even work against extensively drug-resistant TB.” The maps also showed the reason that some of the TB drugs are stronger while others are weaker. This could help scientists develop fluoroquinolones that are more efficient against the mutating disease “This result means the fluoroquinolones aren’t working in the most straightforward way, and that’s a challenge for drug developers,” Berger said. “We have to rethink the chemistry of these drugs, but doing so will likely open up new avenues for improvements.” The study is available in the Proceedings of the National Academy of Sciences.

Source: Johns Hopkins researchers identify TB’s natural resistance to antibiotics