The new study finds the gene GIGYF1 plays a significant role in how likely people are to lose the Y chromosome. In turn, this also sends their risk of developing type 2 diabetes skyrocketing.
Researchers find around one in 3,000 people carry the GIGYF1 genetic variant, leading to a 30-percent chance they’ll develop type 2 diabetes. For comparison, the general population only has a five percent chance of developing diabetes on average.
“Reading an individual’s DNA is a powerful way of identifying genetic variants that increase our risk of developing certain diseases. For complex diseases such as type 2 diabetes, many variants play a role, but often only increasing our risk by a tiny amount. This particular variant, while rare, has a big impact on an individual’s risk,” says Dr. John Perry in a university release.
Additionally, people who carry the GIGYF1 gene have more signs of aging such as weaker muscle strength and more body fat.