Protection against filovirus (ebola) diseases by a novel broad-spectrum nucleoside analogue BCX4430 : Nature : Nature Publishing Group

  1. Good and bad – the researchers know what they are doing but Ft. Detrick is also the place were nerve gas was tested and developed. The close ties between testing for cures and for militarizing things troubles more than a few people.

(Very shortly now, I expect rumors will begin that these labs or someone else is behind the MERS-CoV epidemic in Saudi Arabia and UAE)

Most importantly, BCX4430 completely protects cynomolgus macaques from Marburg virus infection when administered as late as 48 hours after infection. In addition, BCX4430 exhibits broad-spectrum antiviral activity against numerous viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses and flaviviruses. This is the first report, to our knowledge, of non-human primate protection from filovirus disease by a synthetic drug-like small molecule.

via Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 : Nature : Nature Publishing Group.

Who did the research?

  1. Division of Molecular and Translational Sciences, Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland 21702, USA

    • Travis K. Warren,
    • Jay Wells,
    • Rekha G. Panchal,
    • Kelly S. Stuthman,
    • Nicole L. Garza,
    • Sean A. Van Tongeren,
    • Lian Dong,
    • Cary J. Retterer,
    • Brett P. Eaton,
    • Gianluca Pegoraro,
    • Shelley Honnold,
    • Lisa S. Welch &
    • Sina Bavari
  2. BioCryst Pharmaceuticals Inc., Durham, North Carolina 27703, USA

    • Shanta Bantia,
    • Pravin Kotian,
    • Xilin Chen,
    • Brian R. Taubenheim,
    • Yarlagadda S. Babu &
    • William P. Sheridan
  3.